Science Behind Longevix | Evidence-Based Longevity Supplements

Evidence-Based Formulations

At Longevix, we believe that longevity supplements should be grounded in rigorous scientific research. Our formulations are developed based on the latest peer-reviewed studies and are designed to target key biological mechanisms of aging.

We prioritize ingredients with strong clinical evidence, optimal bioavailability, and proven safety profiles. Each product is meticulously crafted to deliver effective doses of compounds that have demonstrated potential benefits for healthspan extension.

Our commitment to scientific integrity means we don't follow trends—we follow the evidence. We're transparent about what the research actually says, helping you make informed decisions about your longevity journey.

Key Ingredients & Their Scientific Basis

Explore the science behind our core ingredients and their potential roles in supporting healthy aging.

NMN

Nicotinamide Riboside

TMG

Resveratrol

Creatine

Nicotinamide Mononucleotide (NMN)

Precursor to NAD+

Nicotinamide Mononucleotide (NMN) is a direct precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme found in every cell of your body that is involved in hundreds of metabolic processes.

Key Research Findings

NAD+ levels decline with age, contributing to age-related metabolic changes and cellular dysfunction
NMN supplementation has been shown to increase NAD+ levels in multiple animal models
Studies suggest NMN may support mitochondrial function, energy metabolism, and DNA repair
Research indicates potential benefits for cardiovascular health, insulin sensitivity, and neuroprotection

How It Works

NMN is converted into NAD+ through a series of biological reactions. NAD+ serves as fuel for several important enzymes, including sirtuins (SIRT1–SIRT7), which play key roles in regulating cellular health, metabolism, and aging processes. NAD+ also functions as a cofactor for PARPs (poly-ADP-ribose-polymerases), enzymes involved in DNA repair.

Our Formulation

We use 99%+ pure NMN in both powder and capsule forms, with third-party verification of purity and potency. Our NMN is stable, bioavailable, and provided at clinically relevant doses based on current research.

Key Research Studies

Our formulations are informed by scientific research. Here are some of the key studies that support our approach.

Cell Metabolism, 2016 Mouse Study

NMN Supplementation

Demonstrated that NMN supplementation can compensate for age-related NAD+ decline and improve various metabolic parameters in aging mice.

Nature Communications, 2019 Human Trial

NR Safety & Metabolism

Confirmed the safety and bioavailability of nicotinamide riboside in humans and its effectiveness at boosting NAD+ levels.

Science, 2013 Cell Study

Resveratrol & Sirtuins

Elucidated the mechanism by which resveratrol activates sirtuins and may mimic some aspects of caloric restriction.

NAD+ Biology & Aging

The decline of NAD+ is considered one of the hallmarks of aging. This essential coenzyme plays critical roles in energy metabolism, DNA repair, and cellular signaling.

As we age, NAD+ levels decrease due to increased consumption by enzymes like CD38 and reduced production. This decline is associated with mitochondrial dysfunction, metabolic changes, and impaired cellular repair mechanisms.

By providing precursors like NMN and NR, we aim to support the body's natural NAD+ biosynthesis pathways, potentially helping to maintain healthier NAD+ levels as we age.

Our formulations are designed to work synergistically with the body's biochemistry, supporting multiple pathways involved in healthy aging rather than targeting just a single mechanism.

Science FAQs

What's the difference between NMN and NR?

Both NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are precursors to NAD+. NMN is converted to NR before entering cells, where it's then converted to NAD+. Some research suggests NMN may be more stable, while NR has been more extensively studied in human trials. Both effectively boost NAD+ levels through slightly different metabolic pathways.

Why include TMG with NR?

TMG (Trimethylglycine) serves as a methyl donor in the body. NR supplementation requires methyl groups for metabolism, which could potentially deplete the body's methyl reserves. By including TMG, we support healthy methylation processes while taking NR, ensuring optimal metabolic function.

How does resveratrol support longevity?

Resveratrol is a polyphenol that activates sirtuins, a class of proteins involved in cellular regulation and aging. It may mimic some effects of caloric restriction, supporting mitochondrial function, reducing oxidative stress, and promoting cellular repair mechanisms.

What's the scientific basis for your dosages?

Our dosages are based on current clinical research, safety data, and bioavailability studies. For example, our NMN dosages align with human trials showing efficacy at 250-500mg daily. We prioritize evidence over hype, using doses that have demonstrated biological activity in peer-reviewed studies.

Science-Backed Longevity